Shift of paradigm in prenatal diagnosis

Prenatal diagnosis of chromosomal abnormalities--shifting paradigm.

It is very likely that in 10 years time, invasive prenatal diagnostic tests like amniocentesis and chorionic villus sampling (CVS) will join the club of forgotten obstetric procedures like vaginal breech delivery and rotational forceps delivery. In 1968, Henry Nadler1 and his team were the fi rst to report prenatal diagnosis of trisomy 21 from full karyotyping of cultured amniocytes obtained by...

Paradigm Shift

A paradigm shift, suggested by Thomas Kuhn [1], is not just a small change in science, or the modification of a theory. It is a scientific revolution and completely changes the way in which science looks at the world. It often dictates how the public looks at the world. For example, Darwin's theories [2] were intensely debated by scientists and theologians. This debate spilled over into the pub...

Prenatal Diagnosis of Granular Cell Tumor

Congenital granular cell tumor (GCT) is a relatively rare intraoral benign tumor, approximately 200 cases of which have been reported in the neonatal period worldwide. The newborn infant may have feeding problems and respiratory difficulties due to airway obstruction. This lesion may be diagnosed by prenatal ultrasonography and simple resection is mostly required. We report a case of an adult t...

Prenatal Diagnosis, Sampling of Chorionic Villi

Prenatal diagnosis with application of the Amniotic fluid (Amniocentesis: AC) and chorionic villi sampling {CVS) is a general aspect of application in Human Genetics which facilitate the diagnosis of different Genetic defects, enclosing chromosomal abnormalities and Genosomopathies. Diagnosis of Genetic defects for AC and CVS is between 16-20th and 8-12th weeks of gestation respectively. Allica...

paradigm shift of health towards obesity in childhood